Transistor

• You cannot get screwed by levelup decisions; anything you don't pick will eventually come back again.

• The game is effectively a very novel take on a turn-based system; you can fight without using Turn() but it's extremely clunky and awkward unless you upgrade an ability with Ping() and/or Jaunt(), with the exception of
  Snapshots, as it's frequently a good idea to throw a quick attack at them to get rid of their dodginess so you can unload on them without risking them dodging out of your line of fire and whiffing your entire turn().

• On a related note, you shouldn't end a Turn() if it'd mean being in a really awkward position that'll get you killed right afterwards - use the last part of your action running, stunning/charming enemies, or Jaunt()ing away.

• Experiment with your abilities, as there's a lot of weirdly powerful combinations lurking in the skill system and a million ways to break it - pretty much every person who posts about the combat system in the thread for it (don't go there now, it's all spoiler-text blackout CIA documens about the story/ending) posts about how "ughhh ability combo x/y/z is super powerful" and yet they all post about a completely different combination of abilities. If you haven't found an ability combo that clicks for you, keep experimenting - you'll find one.

• Experiment with your load-out constantly. There are a lot of good combos, and sticking with one for the whole game is boring.

• If you don't use the Limiters (optional difficulty elements akin to Bastion's idols), combat will be piss-easy. Tune things how you like it.

• The bonuses on level-up aren't missabl - he choice will come back around again. By the end of the game you should have every program.

• If you like the combat, New Game+ continues to introduce harder versions of enemies (and has its own completely new set of encounters), but also gives you additional copies of your programs, opening up a whole lot more customization.