- When playing on PC, the fanmade open source R.E.L.I.V.E. engine is recommended to fix a variety of compatibility issues with this game and Abe's Exoddus.
- Ducking down at suspicious spots and rolling at walls are key for finding most secrets. That said, even the starting area is littered with endgame difficulty secret areas which makes the optional challenge of rescuing all mudokons on a first playthrough very challenging, even with a guide.
- Unlike the sequel and the remake, the original game is entirely checkpoint-based and saving mudokons from even the most brutal secret area does you no good if you don't make it to the next checkpoint. While not 100% reliable due to inconsistent triggers, it is sometimes possible and less risky to backtrack to a previous checkpoint instead. Checkpoints are marked by a brief diamond-shaped icon appearing above Abe's head.
- Note that checkpoints don't save your game, so you should still save regularly in case of crashes and the like. Loading a game simply returns you to the previous time you reached a checkpoint, so it can't be used to "lock in" current progress.
- In sections where you have to mimic sequences, you need to wait for the entire sequence to finish before repeating it.
- When possessing a slig, the "Freeze" and "Look out" commands cause all nearby mudokons to duck briefly which lets you shoot over them without hitting them.
- Repeating the "Follow me" command after the target has stopped next to Abe has them walk to the same "tile" as Abe, and a third time has them walk past it behind him. This can be useful if you need someone to drop down a ledge you're standing next to.