- You won’t be able to craft all equipment and weapon upgrades in a single playthrough unless you do some serious grinding even after 100% completion. Getting all skills will require close to 100% completion. Prioritize accordingly.
- Nothing that counts towards your completion percentage is missable. You can fast travel back to the first real area of the game (Syria) after you finish the final level, so don’t worry if you miss something.
- There is no new game plus. If you're going for achievements, start on the highest difficulty.
- Don’t spend too much time being frustrated with trying to reach an area you think you should be able to get to or find an item that the map says is where you are. Sometimes as you progress the story new portions of areas open up or the environment changes such that items appear where they were not before.
- Challenges do not generally get map markers. The marker that appears when you begin a challenge marks where you first started it, not where you should go next.