- Enemies will generally keep spawning. You are there to loot, not kill.
- Each new run keeps the upgrades you've built, but loses all the money/ammo/etc. Each run starts with different innate quirks, some ships have booths to gain/swap/remove quirks.
- Shops give you a free fuel and food to pay for the cost of visiting that node.
- You can scrap parts and the interface there will tell you if there's any upgrades remaining that it can be used for.
- Torpedoes are used automatically. Warp keys are used by trying to go somewhere you need a warp key for.
- Most devices can be hacked for various benefits. Play around and see which you think are worth the money.