Wasteland 2

- Don't give your characters weapon skills that use the same type of ammo. So have one guy with assault rifles, one with sniper rifles etc. Ammo can be quite scarce, and splitting it up between multiple people will be a pain in the ass.

- It doesn't really matter where you go first. People say Hightower is easier, but it's entirely a matter of preference. I personally went for the AG center and as long as you play smart you'll be fine.

- Space bar switches between group mode/solo mode, so you can use it to give people individual orders. If you're doing anything that is remotely dangerous, like disarming explosives, send one guy in alone to disarm it... if he gets taken out by a critical failure, it's much easier to patch one person up than perform field triage on your entire squad who happened to get caught in the explosion.

- Going up in rank heals the person being promoted. Healing items are fairly common, but worth taking into account so you don't use them unnecessarily.

- Explore areas thoroughly. You can miss an early NPC who will help you out quite a lot if you don't check everywhere.

- As far as I can tell, there's no real way to fuck up your game irrevocably unless you go out of your way to do so. Go in blind, try not to save scum and just roll with whatever the game throws at you... it will be much more fun/interesting that way.

- If you bust a safe/lock, mechanical repair will help with repairing it to give you another chance. Alarm disarming may work with critical failed electronic locks, but I haven't tried it.

- Animal whisperer is fun and useful! Don't overlook it, it can help out immensely and give you some fun effects.

- Surgeon removes status effects and stabilizes people who are bleeding out. If a person is unconscious, they will eventually recover on their own.