Vampyr

• It is possible to permanently lose out on clues by pissing people off. It's not usually a huge deal, but it's a good idea to choose your words carefully.

• Unlocking all clues for a character (specifically the pillars of community) can offer you alternative ways of solving main quests relating to them. However, those unlocked ways are not automatically guaranteed to be the ideal solution. Use your judgement.

• Many sidequests have two ways of solving them, which can in turn determine whether you get certain clues. Always check the questlog for your options before turning one in.

• Your Mesmerise ability, which gates what people you can chomp down on, is automatically leveled up at certain points in the story.

• Killing a named NPC will always lower the stability of a district in the short term, even if they were total assholes who had it coming.

• Any time you rest to spend XP, time will advance and people may get sick, which lowers district stability. Make sure not to rest too often, or the new sicknesses may get over your head. Waiting until you've banked a couple thousand XP is usually a good idea.

• Endurance is probably the most important stat for combat. Make sure to invest into it early on.

• It's a good idea to have all four types of damage (Melee, Ranged, Blood, and Shadow) available, since most enemies tend to have resistances against some of them.

• Bite is very powerful. If you find yourself struggling with combat, improving Bite damage and using a stunning weapon is a strong option.

• Don't bother buying Milton's shotgun, it's kind of a downgrade from the regular shotgun.

• Killing the priest present in one of the boss fights actually does lock you out of the best ending now. It counts as a murder/embrace - Jonathan's eye color changes and you will no longer receive the reward for having killed no citizens you'd get in Chapter 5. Not sure if this locks you out of the Not Even Once cheevo or not, but I suspect it does.

• Endings: You get the best ending when you do not embrace or murder anyone. You can get the good ending when you embrace/murder four or less people (and the abovementioned priest counts). After that it's bad.

• Always carry a shotgun, in your second weapon set if needed. During upgrading, you will have the option to modify it to do fire or acid damage - go fire as soon as you get the upgrade materials. The best shotgun in the game can be found in Chapter four, which is quite late in the game but the upgrade materials are plentiful enough for this not to be an issue.

• Stun is nice and all but not all enemies can be stunned; make sure to switch weapons to fit the situation. A weapon that can draw blood complements a stunning weapon very nicely.

• Skills: Abyss is hands-down the best skill in the game and the only reliable source of shadow damage at your disposal - Shadow Mist is hard to hit with and Spring's damage is minimal even if you spec the skill for it. Claws can be powerful if leveled with the stun effect but there is no point in leveling them since they do Melee damage just like your weapons.

• When you first enter a new district, make sure to go around its borders and unlock as many gates to other districts as you can. The reason for this is that doors are usually barred from one side and every single one has to be unlocked manually. Opening up direct paths between districts you already visited will save you a lot of time in the long run.

• Visiting the exclamation marks on the map is worth it even if they are out of the way. Specifically, these conversations are required to obtain hints on a character that gives you a truly massive amount of XP when embraced with all hints known.