Assassin's Creed: Brotherhood

- Renovate nearly every shop you come across. In addition to giving you money by the truckfull, you'll more likely have stores very near you when you need to go to one. This seems obvious (and it is), but I was very stingy with renovating stores when I played and wound up having to go halfway across the map to get to the nearest blacksmith or whatever a lot, so it's really convenient.

- Don't sell anything. The shops nearest to Ezio's home base have "Shop Quests", where if you give them 5 of this, 10 of that etc. they'll give you special items. The items you get don't typically sell for that much anyway so no harm no foul.

- Be sure to have the crossbow by the time you get the missions for the War Machines. Reason being is that guards get a bit stronger around that point and throwing knives will just halve their HP rather than one-shot them, and the crossbow fixes this problem nicely.

- Speaking of War Machines, do all of the missions for them, then talk to Leonardo when you're done ASAP. You won't regret it.

- When you get to sequence 8, be sure to talk to Leonardo (even if you have all of his upgrades) before you kick off the endgame for one of the funniest moments in the series.