From Before I Play
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  • Ether is the only permanent resource.
  • Weapons have secondary abilities that carry over between runs but have to be unlocked by using the weapon.
  • Whether malignancy is worth the risk is up to you.
  • Don't be too disheartened by a bad run. The RNG can be particularly harsh sometimes.
  • Blue doorways lead to extra loot. Yellow doorways lead to arena style encounters that lock you in until you defeat the boss.
  • Even in the first area there's a lot of stuff that can't be accessed until you have the appropriate tool for it.
  • If you're playing online you will find bodies of other players. You can spend ether to "Scavenge" them and receive a portion of their resources, or "Avenge" them to receive ether after defeating the enemy that killed them.
  • In a pinch you can rest on the Helios to regain some health.